Membrane permeable local anesthetics modulate NaV1.5 mechanosensitivity
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منابع مشابه
Membrane permeable local anesthetics modulate NaV1.5 mechanosensitivity
Voltage-gated sodium selective ion channel Na(V)1.5 is expressed in the heart and the gastrointestinal tract, which are mechanically active organs. Na(V)1.5 is mechanosensitive at stimuli that gate other mechanosensitive ion channels. Local anesthetic and antiarrhythmic drugs act upon Na(V)1.5 to modulate activity by multiple mechanisms. This study examined whether Na(V)1.5 mechanosensitivity i...
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ژورنال
عنوان ژورنال: Channels
سال: 2012
ISSN: 1933-6950,1933-6969
DOI: 10.4161/chan.21202